Chronic Neutrophilic Leukemia (CNL)
The median age of onset is 67 years. Chromosomal abnormalities are observed in 25% of cases.
A. Conventional Cytogenetic Analysis
- Bone marrow karyotype
- Peripheral blood karyotype without stimulation
B. Molecular Cytogenetic Analysis (FISH)
- Detection of deletion of chromosome 20, del(20q12)
- Detection of deletion of chromosome 11, del(11q)
- Detection of trisomy 9
- Detection of trisomy 21
- Detection of translocation t(9;22)(q34;q11), BCR/ABL1
C. Molecular Genetic Analysis
- Detection of the JAK2 gene V617F point mutation
