Chronic Eosinophilic Leukemia (CEL) / Idiopathic Hypereosinophilic Syndrome (iHES)
This is a rare disease occurring in young and middle-aged men. Using classical cytogenetic analysis, chromosomal abnormalities are observed in 15% of cases.
A. Conventional Cytogenetic Analysis
- Bone marrow karyotype
- Peripheral blood karyotype without stimulation
B. Molecular Cytogenetic Analysis (FISH)
- Detection of deletion of chromosome 20, del(20q12)
- Detection of trisomy 8
- Detection of Y chromosome deletion
- Detection of monosomy or deletion of chromosome 7, -7/del(7q-)
- Detection of deletion of chromosome 17, del(17p13.1), p53 gene
- Detection of translocation t(9;22)(q34;q11), BCR/ABL1
- Detection of deletion of chromosome 4, del(4q12), FIP1L1/PDGFRA
C. Molecular Genetic Analysis
- Detection of the JAK2 gene V617F point mutation
